Factors to consider while buying Headphones with Mic:
Comfort - How a headphone fits on your head is an important thing to consider. If you are going to use them for a long time, bad fitting headphones can physically hurt- meaning you cannot focus on your task at hand.
Microphone - If you decide to go for Headphones to use for communication, then look for one that comes with a quality mic. One more thing to consider is that the mic is perfectly manoeuvrable. Even adjusting a few things by an inch or two can make a big difference in the quality of your communication.
Noise Cancellation Or Reduction - Good noise reduction is key for a headphone for blocking out external noise while communicating, as much as being able to hear your voice in the headphones as you talk. Many headphones offer Active Noise Cancellation (ANC) as well.
Wired or Wireless - If you are looking for reliable Headphones with Mic, it is better to choose wired headphones, as you can find them quick and easy to connect and set up. If you do not want to be tethered to your system with wires, wireless headphones with a microphone are the way to go.
Multipoint Bluetooth (In Case of Wireless) - This is a feature that allows you to easily switch between two devices, and is another helpful feature in the home-office environment.